abstract：:In rats, the concurrent alternate elicitation of epileptiform activity in two forebrain structures can result in both the rapid production of severe seizures and the development of fully generalized seizures in one (dominant) site, while arresting the progress of seizure activity at intermediate stages in the other (s...

journal_title：Epilepsy research

authors： Teskey GC,Thiessen EJ,Gilbert TH

更新日期：1999-04-01 00:00:00

abstract：:Previous studies have demonstrated that remacemide and its desglycinyl metabolite, AR-R 2495AA, reduce neuronal damage in animal models of ischemia, subarachnoid hemorrhage, and traumatic brain injury. The aim of the present study was to investigate whether remacemide hydrochloride also alleviates seizure-induced neur...

journal_title：Epilepsy research

authors： Halonen T,Nissinen J,Pitkänen A

更新日期：1999-04-01 00:00:00

abstract：:The Fourth Eilat Conference on New Antiepileptic Drugs (AEDs) was held at the Royal Beach Hotel, Eilat, Israel, from 6th to 10th September 1998. Epileptologists and scientists from 20 countries attended the conference, which was held to discuss a number of issues in drug development, including outcome assessment in ep...

journal_title：Epilepsy research

authors： Bialer M,Johannessen SI,Kupferberg HJ,Levy RH,Loiseau P,Perucca E

更新日期：1999-03-01 00:00:00

abstract：:With the availability of more stable radiopharmaceuticals, the ictal single photon emission computed tomography (SPECT) perfusion study has emerged as a useful noninvasive functional neuroimaging tool in the presurgical evaluation of patients with medically intractable partial epilepsy. The purpose of this study was t...

journal_title：Epilepsy research

authors： Smith BJ,Karvelis KC,Cronan S,Porter W,Smith L,Pantelic MV,Elisevich K

更新日期：1999-02-01 00:00:00

abstract：:Weak relationships have been reported between subjective complaints of memory deficits and memory performance in neuropsychological tests in patients with temporal lobe epilepsy (TLE). This study investigated whether the individual exposure to cognitive demands in daily life contributes to cancel out the performance-c...

journal_title：Epilepsy research

authors： Gleissner U,Helmstaedter C,Quiske A,Elger CE

更新日期：1998-11-01 00:00:00

abstract：:In a selected group of temporal lobe epilepsy patients with seizures refractory to pharmacological treatment, pharmacological seizure control can be attained by surgical resection of the epileptic zone. We investigated to what extent pharmaco-resistance is reflected in a reduced response at the cellular level, in neur...

journal_title：Epilepsy research

authors： Vreugdenhil M,van Veelen CW,van Rijen PC,Lopes da Silva FH,Wadman WJ

更新日期：1998-09-01 00:00:00

abstract：:The limbic/mesial temporal lobe epilepsy syndrome has been defined as a focal epilepsy, with the implication that there is a well defined focus of onset, traditionally centered around the hippocampus. The pathology of the hippocampus in this syndrome has been well described and a number of physiological abnormalities ...

journal_title：Epilepsy research

authors： Bertram EH,Zhang DX,Mangan P,Fountain N,Rempe D

更新日期：1998-09-01 00:00:00

abstract：:A freezing probe was placed on the skull of postnatal day (PN) 1 rats to induce formation of a cerebrocortical microsulcus. Experimental studies were performed on PN days 21-24. At that time point, Nissl-stained sections revealed the presence of a microsulcus similar to that described in human dysplastic cortex. Immun...

journal_title：Epilepsy research

authors： Hablitz JJ,DeFazio T

更新日期：1998-09-01 00:00:00

abstract：:Status epilepticus (SE) is a common neurological and medical emergency. Despite the significant mortality associated with SE, no human data have been available regarding cardiovascular changes prior to death in patients with this condition. This study was conducted to measure hemodynamic trends in the 24 h prior to de...

journal_title：Epilepsy research

authors： Boggs JG,Marmarou A,Agnew JP,Morton LD,Towne AR,Waterhouse EJ,Pellock JM,DeLorenzo RJ

更新日期：1998-08-01 00:00:00

abstract：UNLABELLED:Gabapentin (GBP) is a non-metabolized antiepileptic drug that is eliminated by renal excretion and displays saturable, dose dependent absorption. The recommended dosing schedule for GBP is t.i.d. At large daily doses, oral bioavailability (F) may be improved by giving the daily dose more frequently. OBJECTI...

journal_title：Epilepsy research

authors： Gidal BE,DeCerce J,Bockbrader HN,Gonzalez J,Kruger S,Pitterle ME,Rutecki P,Ramsay RE

更新日期：1998-07-01 00:00:00

abstract：:This prospective study examined the effects of the new antiepileptic drug (AED) gabapentin (GBP) compared to the standard AED carbamazepine (CBZ) and placebo (PLA) on eye movements, posture and finger force control in 12 healthy volunteers who received single doses of 600 mg GBP and 400 mg CBZ in a placebo-controlled,...

journal_title：Epilepsy research

authors： Noachtar S,von Maydell B,Fuhry L,Büttner U

更新日期：1998-06-01 00:00:00

abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

journal_title：Epilepsy research

authors： Baker GA,Gagnon D,McNulty P

更新日期：1998-05-01 00:00:00

abstract：:This investigation of cognitive functioning in patients with symptomatic localization-related (partial) epilepsy prior to administration of antiepileptic medication is part of a nationwide prospective, double-blind study of drug efficacy and longitudinal changes in cognition associated with seizure disorders. Recently...

journal_title：Epilepsy research

authors： Prevey ML,Delaney RC,Cramer JA,Mattson RH

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To identify predictors of seizure-outcome after epilepsy surgery and validate the findings in an independent series of patients. To use the results to develop a predictive model. METHODS:Sequential patients undergoing resective surgery for medically intractable epilepsy were identified at Yale New Haven Hospit...

journal_title：Epilepsy research

authors： Berg AT,Walczak T,Hirsch LJ,Spencer SS

更新日期：1998-02-01 00:00:00

abstract：:Results of previous studies suggested that the brainstem participates in amygdaloid (AM) kindled seizure generalization and the positive transfer effect at the secondary site AM. This study was undertaken to define the role of the brainstem in the patterning of AM kindling, the maintenance of AM kindled seizure and th...

journal_title：Epilepsy research

authors： Hamada K,Wada JA

更新日期：1998-01-01 00:00:00

abstract：:Involvement of opioid systems in the pathogenesis of absence epilepsy has been postulated. However, the role of the mu opioid receptor has not been fully elucidated as yet. In the present study the role of this receptor in absence epilepsy was investigated autoradiographically and pharmacologically. The density of mu ...

journal_title：Epilepsy research

authors： Przewłocka B,Lasoń W,Turchan J,de Bruin N,van Luijtelaar G,Przewłocki R,Coenen A

更新日期：1998-01-01 00:00:00

abstract：:AWD 140-190 a potent new anticonvulsant was tested on several types of epileptiform activities in entorhinal cortex hippocampal slices. AWD 140-190 suppressed completely and in a dose-dependent manner spontaneous seizure-like events induced by lowering extracellular Ca2+. In the low magnesium model, AWD 140-190 applie...

journal_title：Epilepsy research

authors： Armand V,Rundfeldt C,Heinemann U

更新日期：1997-12-01 00:00:00

abstract：:To clarify the mechanisms of the antiepileptic activity of phenytoin (PHI), the effects of PHT on extracellular and total levels of monoamines (dopamine and serotonin), in rat striatum and hippocampus were studied. The plasma concentrations of PHT associated with therapeutic activity did not affect striatal and hippoc...

journal_title：Epilepsy research

authors： Okada M,Kawata Y,Kiryu K,Mizuno K,Wada K,Inomata H,Tasaki H,Kaneko S

更新日期：1997-09-01 00:00:00

abstract：:Tiagabine is a novel antiepileptic drug which has clinical efficacy against complex refractory and myoclonic seizures. The anticonvulsant mechanism of action of tiagabine results from its blockade of neuronal and glial GABA-uptake, thereby increasing GABA levels in the synaptic cleft. Here we present a comparison of t...

journal_title：Epilepsy research

authors： Dalby NO,Nielsen EB

更新日期：1997-07-01 00:00:00

abstract：:The Neurotoxicity Scale was devised as a patient-based report scale to assess the adverse effects of antiepileptic drugs on cognitive function. In a previous report we reported the clinical validity of the scale, tested in a double-blind randomized study, using a benzodiazepine in normal volunteers. In the present stu...

journal_title：Epilepsy research

authors： Aldenkamp AP,Baker GA

更新日期：1997-06-01 00:00:00

abstract：:The compound 5-(4-chlorophenyl)-2,4-dihydro-4-ethyl-3H-1,2,4-triazol-3-one (MDL 27,192) was evaluated in a variety of rodent models to assess its anticonvulsant profile and its potential neuroprotective activity. MDL 27,192 demonstrated anticonvulsant activity in a wide range of epilepsy models that are genetically-ba...

journal_title：Epilepsy research

authors： Kehne JH,Kane JM,Chaney SF,Hurst G,McCloskey TC,Petty MA,Senyah Y,Wolf HH,Zobrist R,White HS

更新日期：1997-04-01 00:00:00

abstract：:Previous work showed that bilateral lesions made between the inferior and superior colliculi reduced the severity of audiogenic seizures in genetically epilepsy-prone rats (GEPR-9s), and indicated that the connections between these two structures are vital for the propagation of seizure activity. To determine the invo...

journal_title：Epilepsy research

authors： Ribak CE,Manio AL,Navetta MS,Gall CM

更新日期：1997-03-01 00:00:00

abstract：:A randomised, double-blind, placebo-controlled crossover study of add-on remacemide hydrochloride was carried out in epilepsy patients being treated with phenytoin (PHT) monotherapy. Eleven patients were recruited, ten of whom completed the study. Plasma concentration profiles of PHT, remacemide, and its active desgly...

journal_title：Epilepsy research

authors： Leach JP,Girvan J,Jamieson V,Jones T,Richens A,Brodie MJ

更新日期：1997-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of symptomatic epilepsy in young adults. This study examined physiological and anatomical epileptogenic consequences of a prior incident of TBI in rats. Rats were subjected to a fluid percussion brain injury one week prior to experimentation, and in vitro electrophysiolo...

journal_title：Epilepsy research

authors： Coulter DA,Rafiq A,Shumate M,Gong QZ,DeLorenzo RJ,Lyeth BG

更新日期：1996-12-01 00:00:00

abstract：:The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of the fascia dentata and aberrant mossy fiber neoinnervation in human and kainate rat hippocampal epilepsy. Because AMPA sub-units modulate the fast glutamate sy...

journal_title：Epilepsy research

authors： Babb TL,Mathern GW,Leite JP,Pretorius JK,Yeoman KM,Kuhlman PA

更新日期：1996-12-01 00:00:00

abstract：:The experimental antiepileptic drug, levetiracetam (UCB L059), a piracetam analogue has been investigated in photosensitive patients in the "photosensitivity model", an early phase II study. A total of 12 patients (10 females, 2 males) with a mean age of 21.5 years (range 13-38) were investigated during a 3 day period...

journal_title：Epilepsy research

authors： Kasteleijn-Nolst Trenité DG,Marescaux C,Stodieck S,Edelbroek PM,Oosting J

更新日期：1996-11-01 00:00:00

abstract：:The Third Eilat Conference on New Antiepileptic Drugs was held at the Royal Beach Hotel from May 27 to May 30, 1996. Epileptologists and scientists from 20 countries attended the conference, which was held to discuss critical issues in drug development, new antiepileptic drugs (AEDs) in development, progress reports a...

journal_title：Epilepsy research

authors： Bialer M,Johannessen SI,Kupferberg HJ,Levy RH,Loiseau P,Perucca E

更新日期：1996-11-01 00:00:00

abstract：:Acute psychological disorders (APDs) are more common in epilepsy than in the general population, with estimates varying from 2 to 16% depending on the population of patients sampled. APD has traditionally been classified by seizure activity (ictal), the early post-ictal period (post-ictal) and unrelated to seizure act...

journal_title：Epilepsy research

authors： Cockerell OC,Moriarty J,Trimble M,Sander JW,Shorvon SD

更新日期：1996-10-01 00:00:00

abstract：:Fifty-eight patients with drug-resistant partial epilepsy were studied preoperatively by interictal rCBF measurements using 99mTc-HMPAO and a dedicated brain SPECT camera (Tomomatic 64). Follow-up of seizure outcome, using the "Engel score", was at least 3 years. The data were analyzed in a blinded set-up, first visua...

journal_title：Epilepsy research

authors： Andersen AR,Hansen BA,Høgenhaven H,Herning M,Paulson O,Dam M

更新日期：1996-09-01 00:00:00

abstract：:The role of the associative connections in the propagation of epileptiform discharges originating from an acute, localized epileptic focus in the anterior piriform cortex has been characterized recently in the in vitro isolated guinea-pig brain preparation. The present study demonstrates that the dorsal propagation of...

journal_title：Epilepsy research

authors： Biella G,Forti M,de Curtis M

更新日期：1996-07-01 00:00:00

abstract：:Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of H...

journal_title：Epilepsy research

authors： Davies KG,Hermann BP,Dohan FC Jr,Foley KT,Bush AJ,Wyler AR

更新日期：1996-06-01 00:00:00

abstract：:Serum levels of prolactin may increase as a consequence of epileptic seizures. The hormone release is caused by the propagation of epileptic activity, usually from the temporal lobe to the hypothalamic-pituitary axis. Due to the intensity of the epileptic afterdischarge, a rise is seen in approximately 60% of complex ...

journal_title：Epilepsy research

authors： Bauer J

更新日期：1996-05-01 00:00:00

abstract：:The novel anticonvulsant, remacemide HCl [(+/-)-2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide monohydrochloride; FPL12924AA], and a desglycinated metabolite [(+/-)-1-methyl-1,2-diphenylethylamine monohydrochloride; FPL 12495AA] reversibly limited sustained high-frequency repetitive firing (SRF) of sodium-dependent a...

journal_title：Epilepsy research

authors： Wamil AW,Cheung H,Harris EW,McLean MJ

更新日期：1996-02-01 00:00:00

abstract：:Familial frontal epilepsy has been recently described in six pedigrees. All families reported show autosomal dominant inheritance with incomplete penetrance. Affected individuals develop predominantly nocturnal seizures with frontal lobe semiology. In 1959, a genetic mouse model for partial epilepsy, the El mouse, was...

journal_title：Epilepsy research

authors： Lopes-Cendes I,Phillips HA,Scheffer IE,Mulley JC,Desbiens R,Andermann E,Cendes F,Verret S,Andermann F,Berkovic SF

更新日期：1995-11-01 00:00:00

abstract：:The genetically epilepsy-prone rat (GEPR) has become an important model to study genetic predisposition to epilepsy involving not only the brainstem but also forebrain structures. Previous work in CA1 hippocampal cells showed a reduction in spike frequency adaptation and only subtle changes in slow afterhyperpolarizat...

journal_title：Epilepsy research

authors： Verma-Ahuja S,Evans MS,Pencek TL

更新日期：1995-10-01 00:00:00

abstract：:Interictal blood flow single photon emission computed tomography (SPECT) has been considered to be of limited value in the investigation of patients with partial epilepsies. Newer SPECT technologies using brain dedicated multiple detector systems have not been fully evaluated. To study the usefulness of an optimized S...

journal_title：Epilepsy research

authors： Schmitz EB,Costa DC,Jackson GD,Moriarty J,Duncan JS,Trimble MR,Ell PJ

更新日期：1995-06-01 00:00:00

abstract：:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges aft...

journal_title：Epilepsy research

authors： Sugiyama S,Fujii M,Ito H

更新日期：1995-05-01 00:00:00

abstract：:Previous experiments suggest the primary route of valproic acid (VPA) removal from the rabbit central nervous system (CNS) is by probenecid-sensitive transporters at the blood-brain barrier but not at the choroid plexus. The purpose of this study was to determine if other transport mechanisms at the choroid plexus pla...

journal_title：Epilepsy research

authors： Adkison KD,Artru AA,Powers KM,Nochlin D,Shen DD

更新日期：1995-03-01 00:00:00

abstract：:Six anticonvulsant drugs, phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), U-54494A, losigamone (LOS), and D-20443, were studied using rat hippocampal slices and standard electrophysiological techniques. The K+ channel blocker, 4-aminopyridine (4-AP), was used as neuronal stimulant. The extracellular parameters ...

journal_title：Epilepsy research

authors： Yonekawa WD,Kapetanovic IM,Kupferberg HJ

更新日期：1995-02-01 00:00:00

abstract：:We analyzed 91 psychomotor seizures from 31 patients seizure free at least one year after temporal lobectomy (implying temporal lobe onset). Fifty symptoms were looked for in every seizure and their time of onset and ending noted. Statistical analysis was used to define symptom clusters and the order of appearance of ...

journal_title：Epilepsy research

authors： Kotagal P,Lüders HO,Williams G,Nichols TR,McPherson J

更新日期：1995-01-01 00:00:00